Science

LC-MS/MS is widely used and offers outstanding sensitivity. Triple-quadrupole mass spectrometry (MS/MS) offers additional benefits due to its selectivity. It can only distinguish compounds by their mass-to-charge ratios (m/z), which is inadequate for most real-world applications. Liquid chromatography mass spectrometry (LC-MS) is a powerful technique widely used in many laboratories. It has shown to be a powerful, qualitative and quantitative analytical tool. LC/MS offers outstanding sensitivity. Triple-quadrupole mass spectrometry MS/MS offers additional benefits due to its selectivity, which makes it an important constituent component of modern research and clinical laboratories worldwide.  In most applications, it is essential to isolate compounds from samples containing thousa...

Pharmacokinetic studies provide the basis for determining drug exposures in the body over time. PK parameters are used to evaluate the absorption, distribution, metabolism, and excretion (ADME) processes of drugs. These ADME processes are affected by physicochemical activities including lipophilicity, molecular weight and water solubility. An understanding of these characteristics is key to designing a successful drug treatment. Absorption is the first topic of pharmacokinetic studies. PK lab testing can be conducted using a variety of methods including oral, nasal, dermal, or parenteral methods of administration. Physicochemical parameters of the drug and the concentration of the drug at the site of absorption will affect how quickly it reaches your bloodstream. Pk bioanalysis provide...